Probing lipid bilayer mobility at specific depths using vibrational spectroscopy
Igor Rubstov, Tulane University
2 – 3:30PM
Monday Apr 29, 2019
POB 6.304
Abstract
We developed small size vibrational labels capable of testing membrane mobility via two-dimensional infrared spectroscopy. Despite low polarity of the membrane interior, the vibrational label shows a significant inhomogeneous linewidth, which enables measuring accurately lipid membrane mobilities via time-resolved spectral diffusion technique. Because of its small size, the label can be anchored to a specific depth in a bilayer, assessing its local mobility.